--- title: Progranulin – Marker of Neuroinflammation description: Progranulin is a stress-induced protein with major roles in cancer, inflammation, metabolic diseases and neurodegeneration. image: https://resources.biomol.com/hubfs/Imported_Blog_Media/Progranulin-2.png --- en EN DE [** My account ](https://www.biomol.com/account) ** Service/Help - [Contact](https://www.biomol.com/contact) - [Technical Service](https://www.biomol.com/technical-service) - [FAQ](https://www.biomol.com/faq) - [Shipping Costs](https://www.biomol.com/shipping-costs) - [Product Search Tips](https://www.biomol.com/product-search-tips) - [Distributors](https://www.biomol.com/distributors) - [Company History](https://www.biomol.com/company-history) - Cookie Settings - [** Menu ](https://resources.biomol.com/biomol-blog/progranulin-marker-of-neuroinflammation#offcanvas--left) - [**Search Tips ](https://www.biomol.com/product-search-tips) - [** Search ](https://resources.biomol.com/biomol-blog/progranulin-marker-of-neuroinflammation#show-hide--search) ** Search   - 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PGRN is an abundant, non-conventional, stress-induced, extracellular matrix-bound secreted growth factor-like molecule and cytoplasmic chaperone, that functions in a cellular and disease specific pattern. PGRN binds to several functionally different receptor families in a cell/tissue specific and condition/disease-dependent manner. For example, PGRN binding with TNFR and DR3 has an important anti-inflammatory role in immune cells, particularly Tregs and macrophages. PGRN/Ephrin type-A receptor 2 (EphA2) interaction is involved in the proliferative influence of PGRN. PGRN binds and activates Notch receptors, enhancing the regenerative capacity of injured neurons. PGRN is also a lysosomal resident protein and sortilin and lipoprotein receptor-related protein 1 (LRP1) have been demonstrated to be the lysosomal trafficking receptors for PGRN with the help of Prosaposin. In the brain, PGRN is primarily expressed in mature neurons and microglia. Absence of progranulin in microglia causes increased production and release of multiple cytokines, suggesting that PGRN regulates microglia activation. PGRN seems to affect microglial proliferation, recruitment, differentiation, activation and phagocytosis, suggesting that PGRN plays a central role in the regulation of neuroinflammatory responses. In neurons, PGRN i) co-localizes in late endosomes and early lysosomes with the transmembrane protein TMEM106B, ii) co-localizes with markers such as BDNF along axons, iii) influences synaptic structure and function at synaptic and extra-synaptic sites, where it is secreted in an activity-dependent manner, and iv) extracellular PGRN is endocytosed and delivered to lysosomes. The lysosomal function of PGRN is not well characterized, but probably involves regulation of proteins such as cathepsins, glucocerebrosidase (GBA) or TMEM106B and likely contributes to neurodegeneration. ## Standard Progranulin ELISA Kits [Progranulin (human) ELISA Kit](https://www.biomol.com/products/assay-kits/elisa-and-immunoassays/progranulin-human-elisa-kit-ag-45a-0018yek-ki01) - **Detection Type:** Colorimetric - **Assay Type:** Sandwich - **Sample Type:** Cell Culture Supernatant, Plasma, Serum - **Sensitivity:** 32 pg/ml - **Range:** 0.063 to 4 ng/ml. ### ![AG-45A-0018YEK-KI01](https://resources.biomol.com/hs-fs/hubfs/Imported_Blog_Media/AG-45A-0018YEK-KI01-2.png?width=400&name=AG-45A-0018YEK-KI01-2.png) [Progranulin (mouse) ELISA Kit](https://www.biomol.com/products/assay-kits/elisa-and-immunoassays/progranulin-mouse-elisa-kit-ag-45a-0019yek-ki01) - **Detection Type:** Colorimetric - **Assay Type:** Sandwich - **Sample Type:** Cell Culture Supernatant, Serum - **Sensitivity:** 60 pg/ml - **Range:** 0.125 to 8 ng/ml ### ![AG-45A-0019YEK-KI01](https://resources.biomol.com/hs-fs/hubfs/Imported_Blog_Media/AG-45A-0019YEK-KI01-2.png?width=400&name=AG-45A-0019YEK-KI01-2.png) ### [Progranulin (rat) ELISA Kit](https://www.biomol.com/products/assay-kits/elisa-and-immunoassays/progranulin-rat-elisa-kit-ag-45a-0043yek-ki01) - **Detection Type:** Colorimetric - **Assay Type:** Sandwich - **Sample Type:** Cell Culture Supernatant, Serum - **Sensitivity:** 40 pg/ml - **Range:** 0.063 to 4 ng/ml ## ![AG-45A-0043YEK-KI01](https://resources.biomol.com/hs-fs/hubfs/Imported_Blog_Media/AG-45A-0043YEK-KI01-2.png?width=400&name=AG-45A-0043YEK-KI01-2.png) [**All Products from AdipoGen Life Sciences**](https://www.biomol.com/adipogen/)   ## References 1. [The lysosomal function of progranulin, a guardian against neurodegeneration: D.H. Paushter, et al.; Acta Neuropathol. 136, 1 (2018)](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117207/). 2. [Progranulin: A conductor of receptors orchestra, a chaperone of lysosomal enzymes and a therapeutic target for multiple diseases: Y. Cui, et al.; Cytokine Growth Factor Rev. 45, 53 (2019)](https://www.ncbi.nlm.nih.gov/pubmed/30733059) ## You might also like... 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