---
title: Using Existing Therapeutics Against COVID-19
description: Currently, there are no approved drugs to treat the SARS-CoV-2 infection that causes COVID-19. Existing drugs are being examined.
image: https://resources.biomol.com/hubfs/Imported_Blog_Media/COVID-19-Therapeutics-2.png
---
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# Using Existing Therapeutics Against COVID-19
Written by: Dr. Balint Földesi 03-18-2020
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[Share on Whatsapp ](whatsapp://send?text=https://resources.biomol.com/biomol-blog/using-existing-therapeutics-against-covid-19) [Share on X ](https://twitter.com/intent/tweet?source=https://resources.biomol.com/biomol-blog/using-existing-therapeutics-against-covid-19&text=Using%20Existing%20Therapeutics%20Against%20COVID-19%20-%20https://resources.biomol.com/biomol-blog/using-existing-therapeutics-against-covid-19) [Share on LinkedIn ](https://www.linkedin.com/shareArticle?mini=true&url=https://resources.biomol.com/biomol-blog/using-existing-therapeutics-against-covid-19) [Share on Facebook ](https://www.facebook.com/sharer/sharer.php?u=https://resources.biomol.com/biomol-blog/using-existing-therapeutics-against-covid-19)
Note: The products listed in this article are for biomedical research only. They are *not* for human or veterinary use.
Currently, there are no approved drugs to treat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that causes coronavirus disease 2019 (COVID-19). Existing drugs that have a known favorable safety profile are being examined for strategies to treat the disease and fast-track a treatment plan. The influenza drug favilavir (favipiravir; sold for research use only under the name [T-705](https://www.biomol.com/search?sSearch=259793-96-9)) has just been approved as an investigational therapy in the US, and the Ebola virus drug [remdesivir](https://www.biomol.com/search?sSearch=1809249-37-3) is currently undergoing clinical trial in coronavirus patients in China. The rational selection of drugs already on the market is being made based on their ability to inhibit any proteins essential for virus-receptor interaction and/or viral life cycle.
Various potential targets for development of COVID-19 therapeutics exist along the stages from when a positive-sense, single-stranded RNA virus infects host cells and replicates. With little time available for drug testing and development, the repurposing of approved pharmaceutical drugs provides the most immediate solution for addressing the COVID-19 outbreak. Indeed, knowledge gained from the previous SARS outbreak has placed researchers in an advantageous position of better understanding solutions of how to address long-term treatment of this newly identified coronavirus.
| **Compound** | **Mechanism** | **Publications** |
| --- | --- | --- |
| [Arbidol](https://www.biomol.com/search?sSearch=131707-23-8) (Umifenovir) | Viral membrane fusion inhibitor | - [Arbidol Combined With LPV/r Versus LPV/r Alone Against Corona Virus Disease 2019 : a Retrospective Cohort Study](https://doi.org/10.1016/j.jinf.2020.03.002) |
| [Camostat](https://www.biomol.com/search?sSearch=59721-29-8) | Protease inhibitor | - [SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a 2 clinically-proven protease inhibitor](https://doi.org/10.1016/j.cell.2020.02.052) |
| [Cefuroximine](https://www.biomol.com/search?sSearch=56238-63-2) | Multi-target inhibitor | - [Repurposing cefuroxime for treatment of COVID-19: a scoping review of* in silico* studies](https://doi.org/10.1080/07391102.2020.1777904) |
| [Chloroquine](https://www.biomol.com/search?sSearch=50-63-5) (CQ) / [Hydoxychloroquine](https://www.biomol.com/search?sSearch=747-36-4) | Zinc ionophore | - [Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) *in vitro*](https://doi.org/10.1038/s41422-020-0282-0) - [*In Vitro* Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)](https://doi.org/10.1093/cid/ciaa237) - [Chloroquine Is a Zinc Ionophore](https://doi.org/10.1371/journal.pone.0109180) |
| [Fluoxetine](https://www.biomol.com/search?sSearch=56296-78-7) | Viral replication inhibitor | - [The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2](https://doi.org/10.1101/2020.06.14.150490) |
| [GS-441524](https://www.biomol.com/search?sSearch=1191237-69-0) | Antiviral adenosine analog | - [Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) *in vitro*](https://doi.org/10.1038/s41422-020-0282-0) |
| [Ivermectin](https://www.biomol.com/products/chemicals/biochemicals/ivermectin-lkt-i8618.1) | IMPα/β1 inhibitor | - [The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 *in vitro*](https://doi.org/10.1016/j.antiviral.2020.104787) |
| [MK-2206](https://www.biomol.com/search?sSearch=1032350-13-2) | AKT inhibitor | - [Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics](https://doi.org/10.1101/2020.04.15.997254) |
| [Lopinavir](https://www.biomol.com/search?sSearch=192725-17-0) / [Ritonavir](https://www.biomol.com/search?sSearch=155213-67-5) (Kaletra, LPV/r) | CYP enzyme inhibitor | - [Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings](https://doi.org/10.1136/thorax.2003.012658) |
| [Nafamostat](https://www.biomol.com/products/chemicals/biochemicals/nafamostat-mesylate-cay14837-5) | Protease inhibitor | - [Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) *in vitro*](https://doi.org/10.1038/s41422-020-0282-0) |
| NHC, EIDD-1931 | Antiviral ribonucleoside analog | - [An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus](https://doi.org/10.1101/2020.03.19.997890%20) |
| [Niclosamide](https://www.biomol.com/search?sSearch=50-65-7) | Beclin-1 stabilizer | - [Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics](https://doi.org/10.1101/2020.04.15.997254) |
| [Nitazoxanide](https://www.biomol.com/search?sSearch=55981-09-4) | Antiviral | - [Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) *in vitro*](https://doi.org/10.1038/s41422-020-0282-0) |
| [Penciclovir](https://www.biomol.com/search?sSearch=39809-25-1) | Antiviral guanosine analog | - [Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) *in vitro*](https://doi.org/10.1038/s41422-020-0282-0) |
| [Remdesivir ](https://www.biomol.com/search?sSearch=1809249-37-3)(GS-5734, RDV) | Prodrug form of GS-441524 | - [Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) *in vitro*](https://doi.org/10.1038/s41422-020-0282-0) - [Compassionate Use of Remdesivir for Patients with Severe Covid-19](https://doi.org/10.1056/NEJMoa2007016) |
| [Ribavirin](https://www.biomol.com/search?sSearch=36791-04-5) | Antiviral guanosine analog | - [Inhibition of SARS Coronavirus Infection *In Vitro* with Clinically Approved Antiviral Drugs](https://dx.doi.org/10.3201%2Feid1004.030458) - [Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) *in vitro*](https://doi.org/10.1038/s41422-020-0282-0) |
| [Spermidine](https://www.biomol.com/search?sSearch=124-20-9) | Autophagy inducer | - [Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics](https://doi.org/10.1101/2020.04.15.997254) |
| [T-705](https://www.biomol.com/search?sSearch=259793-96-9) (Favipiravir) | RdRP inhibitor | - [Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) *in vitro*](https://doi.org/10.1038/s41422-020-0282-0) - [T-705 induces lethal mutagenesis in Ebola and Marburg populations in macaques](https://doi.org/10.1016/j.antiviral.2019.06.001) |
| Zinc | RdRP inhibitor | - [Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture](https://doi.org/10.1371/journal.ppat.1001176) - [Chloroquine Is a Zinc Ionophore](https://doi.org/10.1371/journal.pone.0109180) |
### Photo Credit
Alissa Eckert, MS, Dan Higgins, MAMS
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