---
title: ACE2 - The SARS-CoV-2 Receptor
description: The novel coronavirus SARS-CoV-2 which causes COVID-19, shares 79.5% sequence identity with the virus responsible for SARS.
image: https://resources.biomol.com/hubfs/Imported_Blog_Media/ACE2-The-SARS-CoV-2-Receptor-2.jpg
---

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- ACE2 - The SARS-CoV-2 Receptor

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# ACE2 - The SARS-CoV-2 Receptor

Written by: Dr. Balint Földesi  02-12-2020

Share post on social media:

[Share on Whatsapp ](whatsapp://send?text=https://resources.biomol.com/biomol-blog/ace2-the-sars-cov-2-receptor) [Share on X ](https://twitter.com/intent/tweet?source=https://resources.biomol.com/biomol-blog/ace2-the-sars-cov-2-receptor&text=ACE2%20-%20The%20SARS-CoV-2%20Receptor%20-%20https://resources.biomol.com/biomol-blog/ace2-the-sars-cov-2-receptor) [Share on LinkedIn ](https://www.linkedin.com/shareArticle?mini=true&url=https://resources.biomol.com/biomol-blog/ace2-the-sars-cov-2-receptor) [Share on Facebook ](https://www.facebook.com/sharer/sharer.php?u=https://resources.biomol.com/biomol-blog/ace2-the-sars-cov-2-receptor)

![ACE2 - The SARS-CoV-2 Receptor](https://resources.biomol.com/hubfs/Imported_Blog_Media/ACE2-The-SARS-CoV-2-Receptor-2.jpg)

The SARS-Coronavirus (SARS-CoV), first discovered 18 years ago, leads to respiratory diseases in infected people.[1](https://resources.biomol.com/biomol-blog/ace2-the-sars-cov-2-receptor#References) To date there are no effective vaccines against any type of the coronavirus, which can cause pneumonia and possibly bronchitis.[2](https://resources.biomol.com/biomol-blog/ace2-the-sars-cov-2-receptor#References) It was found that bats are the natural host of SARSr-CoV (SARS-related coronaviruses).

ACE2 (angiotensin-converting enzyme-2) was previously reported to be the receptor for SARS-CoV and is highly concentrated in airway epithelial cells. SARS-CoV shares 79.5% sequence identity with the novel coronavirus SARS-CoV-2 that causes COVID-19. Based on structural analysis, Wan *et al.*, and Xu *et al.*, found that ACE2 could indeed also be the receptor for SARS-CoV-2.[3,4](https://resources.biomol.com/biomol-blog/ace2-the-sars-cov-2-receptor#References)

The first promising data about this topic was published in *Nature *on Febuary 3rd 2020. Zhou *et al.*, conducted virus infectivity studies and confirmed that ACE2 is required for entry of SARS-CoV-2 into HeLa cells and bats[5](https://resources.biomol.com/biomol-blog/ace2-the-sars-cov-2-receptor#References) (Fig. 1). Interestingly the virus could not use the ACE2 receptor to infect mouse cells. The researchers also showed that the SARS-CoV-2 does not use other coronavirus receptors like the aminopeptidase N and dipeptidyl peptidase.[5](https://resources.biomol.com/biomol-blog/ace2-the-sars-cov-2-receptor#References)

 ![ACE2-Receptor](https://resources.biomol.com/hs-fs/hubfs/Imported_Blog_Media/ACE2-Receptor-2.jpg?width=700&name=ACE2-Receptor-2.jpg)

Figure 1: Fluorescence image of the SARS-CoV-2 receptor usage. Infection of HeLa Cells with or without the expression of ACE2 receptor. h = human. b = bat. Adapted from: Zhou *et al.*, 2020. This image is used under the [creative commons attribution 4.0 license](http://creativecommons.org/licenses/by/4.0/).

## SARS-Cov-2 Cell Entry Is Blocked by *Camostat Mesylate*

In a paper published in *Cell* on March 5th 2020, Hoffmann M. *et al.* describe how the virus uses the viral spike (S) protein to enter the host cell via ACE2 binding[6](https://resources.biomol.com/biomol-blog/ace2-the-sars-cov-2-receptor#References). They show that host cell entry of SARS-CoV-2 depends on a process called S protein priming, which is carried out by cellular proteases such as serine protease TMPRSS2. This crucial step leads to fusion of viral and cellular membranes. Hoffmann M. *et al.* also found that TMPRSS2 activity is essential for viral spread and inhibition of TMPRSS2 with the protease inhibitor [camostat mesylate](https://www.biomol.com/search?sSearch=Camostat%20Mesilate%20(FOY-305)&sSearchOriginal=camostat%20mesilate) can block infection of lung cells. With no vaccination at hand, further understanding of SARS-CoV-2-ACE2 interactions can offer treatment options and lead to anti-infective strategies such as the development of neutralizing antibodies.

 

![TMPRSS2](https://resources.biomol.com/hubfs/Imported_Blog_Media/TMPRSS2-2.png)Figure 2: The viral spike protein of the new coronavirus SARS-CoV-2 uses the same cellular receptor (ACE2) as SARS-CoV and requires the cellular protease TMPRSS2 for its activation. Figure: Markus Hoffmann / German Primate Centre.

## ACE2 Antibodies & ELISA Kits

### [Anti-ACE2 (human), mAb (blocking) (AC384) (preservative free)](https://www.biomol.com/products/antibodies/primary-antibodies/general/anti-ace2-human-mab-blocking-ac384-preservative-free-ag-20a-0037pf-c100)

AdipoGen Life Sciences produces a unique monoclonal ACE2 blocking antibody.

![AG-20A-0037PF-C100](https://resources.biomol.com/hs-fs/hubfs/Imported_Blog_Media/AG-20A-0037PF-C100-2.png?height=170&name=AG-20A-0037PF-C100-2.png)

- **Item number: **AG-20A-0037PF-C100
- **Antibody type: **Monoclonal
- **Reactivity:** Human
- **Host:** Mouse
- **Application:** ELISA, WB, FA

### [Anti-ACE2 (human) Antibody, clone AC18F](https://www.biomol.com/products/antibodies/primary-antibodies/general/anti-ace2-human-clone-ac18f-ag-20a-0032-c050)

AdipoGen Life Sciences produces a monoclonal ACE2 antibody that is suitable for the use in flow cytometry.

![AG-20A-0032-C050](https://resources.biomol.com/hs-fs/hubfs/Imported_Blog_Media/AG-20A-0032-C050-3.png?height=170&name=AG-20A-0032-C050-3.png)

- **Item number: **AG-20A-0032-C050
- **Antibody type: **Monoclonal
- **Reactivity:** Human
- **Host:** Mouse
- **Application:** FC, ELISA, WB

### [Anti-ACE2 Antibody](https://www.biomol.com/products/antibodies/primary-antibodies/general/anti-ace2-arg41099.100?fs=904683353)

Arigo Biolaboratories offers an IP-grade Anti-ACE2 antibody that is excellent for studying SARS-CoV-2-ACE2 interactions and viral infections.

![ARG41099-100](https://resources.biomol.com/hs-fs/hubfs/Imported_Blog_Media/ARG41099-100-4.jpg?width=100&height=170&name=ARG41099-100-4.jpg)

- **Item number: **ARG41099.100
- **Antibody type: **Polyclonal
- **Reactivity:** Human, Mouse, Rat
- **Host:** Rabbit
- **Application:** IHC-P, IP, WB

### [Human ACE2 ELISA Kit](https://www.biomol.com/products/assay-kits/elisa-and-immunoassays/human-ace2-elisa-kit-arg80959.96)

![ARG80959-96](https://resources.biomol.com/hs-fs/hubfs/Imported_Blog_Media/ARG80959-96-2.jpg?width=288&height=170&name=ARG80959-96-2.jpg)

- **Item number: **ARG80959.96
- **Sensitivity:** 12.5 pg/ml
- **Sample:** Serum, plasma, lysate, cell culture supernatant
- **Range**: 62.5 to 4000 pg/ml

## References

1. [Smith and Richard D. (2006) Responding to global infectious disease outbreaks: Lessons from SARS on the role of risk perception, communication and management, *Social Science & Medicine*. 63, 3113–23. ](https://doi.org/10.1016%2Fj.socscimed.2006.08.004)
2. [Forgie S. and Marrie T.J. (2009) Healthcare-associated atypical pneumonia *Seminars in Respiratory and Critical Care Medicine*. 30, 67-85](https://doi.org/10.1055%2Fs-0028-1119811)
3. [Wan et al., (2020) Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS. *Journal of Virology*.](https://arigobio.us15.list-manage.com/track/click?u=39d1ebd12f4b48daf75f6066a&id=7e09884366&e=c58c24f57c)
4. [Xu et al., (2020) Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. *SCIENCE CHINA Life Sciences* 63.](https://arigobio.us15.list-manage.com/track/click?u=39d1ebd12f4b48daf75f6066a&id=78acc9db41&e=c58c24f57c)
5. [Zhou et al., (2020) A Oneumonia Outbreak Associated With a New Coronavirus of Probable Bat Origin, *Nature Article* ](https://doi.org/10.1038/s41586-020-2012-7)
6. [Hoffmann M. et al., (2020) SARS-CoV-2 cell entry depends on A 1 CE2 and TMPRSS2 and is blocked by a 2 clinically-proven protease inhibitor. *Cell*](https://doi.org/10.1016/j.cell.2020.02.052)

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 The virus family of Coronaviridae contains single stranded, positive-sense RNA viruses. They belong to the order of Nidovirales and are...

- [Antibodies](https://resources.biomol.com/biomol-blog/tag/antibodies)
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![Using Existing Therapeutics Against COVID-19](https://resources.biomol.com/hs-fs/hubfs/Imported_Blog_Media/COVID-19-Therapeutics-2.png?width=600&name=COVID-19-Therapeutics-2.png)

##### Using Existing Therapeutics Against COVID-19

 Note: The products listed in this article are for biomedical research only. They are not for human or veterinary use.

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